Some https://datingranking.net/it/incontri-wiccan/ other education mentioned CRP try found the partnership but in these studies the new seemingly small number of users were the fresh new limiting basis [20, 21]
The frequency of vitamin D deficiency was evaluated between outpatient and hospitalized patients groups in this study population. The incidence of vitamin Dstep three deficiency in all-cause hospitalized patients was more frequent ( ). The prevalence of vitamin D3 deficiency in outpatients was 46.3% ( ) and in hospitalized patients was 67.5% ( ). The number of subjects with normal vitamin D3 was 53.7% for outpatients ( ) and for hospitalized patients was 32.4% ( ), respectively (Table 6). Moreover age, ESR, WBC, and CRP medians had higher levels in hospitalized patients.
Finally, B12 levels were measured in 254 patients. The prevalence of low vitamin B12 (<160 pg/mL) was 68% ( ), and the prevalence of normal vitamin B12 level (>160 pg/mL) was 32% ( ) in the group with vitamin D3 deficiency, whereas the prevalence of low vitamin B12 was 51.4% ( ), and the prevalence of normal vitamin B12 (Number 30) was 48.6% ( ) in the normal vitamin D3 group. Vitamin B12 deficiency was more frequently seen in patients with vitamin D3 deficiency ( ) (Table 6).
4. Conversation
Present study did not reflect the true incidence of vitamin D3 deficiency because patients who are thought to lack of vitamin D3 were included in this study. A limited number of studies conducted in Turkey have shown that vitamin D3 deficiency is a common issue during the fall and winter in individuals, particularly for elderly. The deficiency of vitamin D3 is seen in 70–75% of women in our country. Vitamin D3 deficiency rates are 80–84% in the Middle East, 60–65% in Asia, 50–55% in Europe, and 50% in Latin America [16–18]. Female constitutes the majority of patients may be due to less exposure to the sun and the higher prevalence of osteoporosis.
There was no tall relationship anywhere between years and vitamin D insufficiency and therefore is generally because of personal properties of the read society. But the majority of degree did not stated the partnership anywhere between decades and nutritional D accounts.
In present study we did not find a relationship between vitamin D3 deficiency and inflammatory markers, such as CRP, ESR, and leukocyte counts. In several studies were unknown accompanying diseases, and hospitalization rates [9, 22]. There were no studies evaluating ESR, and leukocyte counts were evaluated in 25-(OH) D3 deficiency.
Sensitive CRP that was not measured is the limitation of the study. To resolve this drawback was categorized patients according to the levels of CRP. Therefore we divided our study populations into subsets according to CRP levels. Firstly, we counted the number of patients with and without vitamin D3 deficiency in CRP normal group. We found no significant difference between two subgroups. Secondly, we separated the study population into CRP normal and significantly high CRP groups. We found no significant difference between the last subgroups again. The reason for this classification was to evaluate the frequency of vitamin D3 deficiency in out-patients with important high level of CRP. Finally, we applied correlation analysis between the level of CRP and 25-(OH) D3. But a relationship between the level of CRP and 25-(OH) D3 was not found in all our analyses. In other words, we did not observe an association between vitamin D deficiency and CRP levels anyway.
Patients’ age, serum albumin, CRP, and ESR levels, leukocyte counts, and creatinine values were significantly different between ambulatory and hospitalized patients. The medians of inflammatory markers of hospitalized patients were higher compared to those of ambulatory patients except albumin levels. In addition, the frequency of 25-(OH) D3 deficiency was higher once again in hospitalized patients. These also mean that 25-(OH) D3 deficiency aggravates all-cause diseases, which is associated with the course of inflammation and infection but not CRP levels.
